Abstract
Hypothalamic tissue extracts of rats were chromatographed and β-endorphin immunoreactivity (β-End i) was measured. The two major peaks of β-End i co-eluted with β-lipotropin (β-LPH) and β-End respectively. Hypophysectomy caused a local decrease of β-LPH and β-End concentrations in the mediobasal hypothalamus. During superfusion of hypothalamic tissue blocks in vitro, membrane depolarization by electric stimulation or 45 mM K + induced a Ca 2+-dependent release of both β-LPH and β-End.
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