Abstract
The release characteristics of mitoxantrone-containing liposomes was studied. The effect of lipid composition on the release rate showed an order of positively charged liposomes > neutral liposomes > negatively charged liposomes. This was attributed to the strength of the binding forces involved in the interaction between the drug and lipids. The release of mitoxantrone from liposomes after the incorporation of galactocerebroside demonstrated no dependence on the molar ratio of added galactocerebroside. This was due to the binding force being insufficient to influence the release rate of the entrapped mitoxantrone significantly. The effect of temperature on the release rate revealed that 4° C may be a suitable temperature for storage of the liposomes during the time range studied, since the release rate was slow. At 4, 25 and 37°C, the release profiles fitted a linear concentration-square root of time plot which demonstrated the diffusion-controlled release of entrapped mitoxantrone from the membrane matrix. The effect of pH on release showed an increase in release rate with increasing pH. At high pH, partitioning of mitoxantrone into the membrane matrix was considerable and drug was released rapidly.
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