Abstract
Dogs with simulated puncture wounds contaminated with reactor produced PuO2 were studied to determine the relative translocation of Pu and Am. Differential distribution of the two elements was observed in both soft and skeletal tissues. Administration of the chelating agent diethylenetriaminepentaacetic acid, DTPA, produced significant effects in the relative concentration of Pu and Am in urine, liver, and femur bone tissues. In-vivo determination of Pu burdens by the 241Am tracer method may produce inaccurate results.
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