Relationships of Psychiatric Comorbidities with the Risk of Hospitalization for Motor Vehicle Crash Injury in Young‐Onset Dementia: A Nationwide Population‐Based Study in Taiwan

Abstract

AbstractBackgroundAlthough the association between young‐onset dementia and hospitalization for motor vehicle crash injury (MVCI) has been shown, little is known about the relationship between the risk of MVCI and psychiatric comorbidities in young‐onset dementia. This study investigates the which psychiatric comorbidities in young‐onset dementia increases the risk of MVCI.MethodIn this retrospective population‐based cohort study, we identified 39,344 dementia aged 40‐64 years from the Taiwan National Health Insurance Research Database (NHIRD) entries between 2006 and 2012. MVCI‐related hospitalization was determined using linked data from the Police‐reported Traffic Accident Registry and the NHIRD between 2006 and 2015. We performed the Cox regression model to estimate the association of the risk of hospitalization for MVCI with young‐onset dementia comorbid with specific psychiatric disorders, including anxiety disorders, depressive disorders, bipolar disorders, alcohol‐related disorders, other substance‐related disorders, and insomnia.ResultOf the 39,344 participants included in the study, all participants encountered 1,013 hospitalizations for MVCI in the 222,239.8 person‐years observed, representing incidence densities of hospitalization for MVCI of 45.58 (95% CI 42.77‐48.39) per 10,000 person‐years. The incidence densities of hospitalization for MVCI increased when young‐onset dementia comorbid with anxiety disorders (56.17 per 10,000 person‐years), depressive disorders (58.61 per 10,000 person‐years), bipolar disorders (83.55 per 10,000 person‐years), alcohol‐related disorders (85.64 per 10,000 person‐years), other substance‐related disorders (84.79 per 10,000 person‐years), and insomnia (59.80 per 10,000 person‐years). However, the risk of hospitalization for MVCI was only significantly increased when young‐onset dementia comorbid with bipolar disorders (HR, 1.60; 95% CI: 1.21‐2.13), alcohol‐related disorders (HR, 1.55; 95% CI: 1.27‐1.90) and insomnia (HR, 1.26; 95% CI: 1.07‐1.47).ConclusionYounger adults with dementia comorbid with specific psychiatric disorders rise the risk of hospitalization for MVCI, which suggests the reinforcement transport safety in those population is needed.