Abstract
The effect of ethionine on the biotin content of liver as well as the effect of biotin deficiency on the development of fatty liver and on lipogenesis in vitro in ethionine-treated rats are reported. The amount of biotin in the livers of ethionine-treated rats was lower than in the controls. In biotin-deficient rats, the development of ethionine-induced fatty liver was inhibited. The incorporation of acetate-1-C 14 into total lipids was decreased in slices from livers of biotin-deficient rats and also from livers of ethionine-treated rats fed on a biotin-free and on a biotin-supplemented diet. The data suggest that there may be a relationship between biotin and ethionine-induced fatty infiltration of the liver.
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