Abstract
Objective To determine the impact of physical activity on the prevalence of fatty liver, metabolic and cardiovascular disease in adult men.Methods This study evaluated 1,399 men (40.7±8.18 years) with body mass index of 26.7kg/m2 (±3.4) who participated in the Protocol of Preventive Health Check-up at Hospital Israelita Albert Einstein from January to October 2011. We conducted tests of serum blood glucose, total cholesterol, LDL, HDL, triglycerides, reactive c-protein, aspartate transaminase, alanine transaminase and gamma-glutamyl transpeptidase. The statistical analysis comprised in the comparison of mean and standard deviation. The analysis of variance was based in two paths of two way ANOVA, Student’s t-test, Mann Whitney U test, Wald test and χ2. We considered a significance level at p<0.05 and correlation of univariate Poison with 95% confidence interval.Results :Fatty liver was diagnosed in 37.0% of the sample. Triglyceride levels of active men with fatty liver were 148.2±77.6mg/dL while inactive men with fatty liver had 173.4±15.6mg/dL. The remaining serum levels were normal. Inactive individuals showed higher values than active. In addition, inactive individuals have 10.68 times higher risk of developing fatty liver compared with active.Conclusion Physical activity improves metabolic parameters such as triglycerides, weight control, HDL, which interfere in the development of fatty liver. Physically active individuals had lower fatty liver prevalence regardless of values of body composition and lipid profile, leading the conclusion that physical activity has a protective role against development of fatty liver.
Highlights
Chronic non-communicable diseases are characterized as sings of worsening in individuals’ health conditions
In the United States fatty liver has an prevalence of 31% among adults, and of these 50% have diabetics and 76% are obese.[1]. In the world, 10% to 24% of adults of both sexes have positive diagnosis to fatty liver,(2) which can be related with unhealthy life habits, such as poor diet and low level of physical activity
Such thing occurs because according to Colberg et al,(8) the increase of physical activity level improves the control of glycemic levels due to use of glucose in muscle tissue, liver gluconeogenesis, insulin independent uptake, weight control, stimulus of GLUT proteins and active kinase protein
Summary
Chronic non-communicable diseases are characterized as sings of worsening in individuals’ health conditions. Evidences presented by Belmonte et al[4] and Lira[5] suggest the importance of moderate aerobic activity as a preventive agent in installation of fatty liver because of the reestablishment of metabolism of lipoprotein and increase in the mitochondrial ability to transport fatty acids in hepatocytes, there is a lack of enough studies showing the relationship between level of exercise and prevalence of fatty liver in adults Such thing occurs because according to Colberg et al,(8) the increase of physical activity level improves the control of glycemic levels due to use of glucose in muscle tissue, liver gluconeogenesis, insulin independent uptake, weight control, stimulus of GLUT proteins and active kinase protein. Exercises of resistance with moderate intensity must be done twice a week in alternated days,(8) but each individual clinical characteristic should be considered
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