RELATIONSHIPS AND SEX DIFFERENCES BETWEEN COGNITION AND SLEEP PARAMETERS AND MEDIATING EFFECTS OF DEPRESSION

Abstract

Sleep variables and depression affect cognition. Depression is associated with undiagnosed sleep problems. Depression is one of the most common psychiatric symptoms in Alzheimer's disease (AD). Recruited 105 samples. Data Collections(sex, age, Ht, BW, BMI, sleep scoring data includingAHI & RDI, PSQI, ESS, SI, BDI, Overnight PSG), IBM SPSS statistics 23.0 version(t-test, Multiple regression analysis I-IV, Mediation effect test of Baron and Kenny. 105 samples (Men 74, Women 31), Age(Men 50.20±15.02,Women 52.58 ±12.97, Mean 50.90±14.43), Height(Men 170.10±6.05cm, Women 155.12±6.27cm, Mean 165.68±9.17cm), Body weight (Men 75.94±14.18kg, Women 60.32±11.94kg, Mean 71.33 ±15.28kg), Body mass index(Men 26.21±4.09, Women 25.15 ±5.23, Mean 25.90±4.45), Neck circumference(Men 38.28±3.18cm, Women 33.66±3.95cm, Mean 36.92±4.01cm, Waist(Men 92.73±11.25cm, Women 83.81±15.69cm, Mean 90.10±13.28cm),t-test(Sex differences) siginificant results(Height, body weight, WASO, Duration N1 stage, Duration N3 stage, AHI, NREM AHI, RDI, NREM RDI, Supine AHI, Supine RDI, Arousal Index, Snoring Index, Mean SpO2, Neck circumference, Waist), Stepwise multiple regression analysis I : Dependent variable Moca-K, endent variable- Age Age(model 1), Adjusted R2=0.092, F=11.494, p=0.001/ Age & Waist(model 2) Adjusted R2 =0.128(Δ 0.036), F=8.629, p=0.000, Stepwise multiple regression analysis II : Dependent variable Moca-K, Independent variable- % N1 stage(model 1) Adjusted R2 =0.107, F=13.469, p=0.000 / % N1 stage & Duration N1(model 2) Adjusted R2 =0.134(Δ 0,027), F=9.079, p=0.000,Stepwise multiple regression analysis III : Dependent variable Moca-K, Independent variable-BDI(model 1) Adjusted R2 =0.057, F=7.260, p= 0,008 / BDI & supine RDI (model 2) Adjusted R2 =0.098, F=6.571, p=0.002. Stepwise multiple regression analysis IV : Dependent variable BDI, Independent variable PSQI(model 1) Adjusted R2 =0.162, F=20.959, p=0.000 / PSQI & Snoring Index(model 2) Adjusted R2 =0.222, F=15.732. p=0.000/PSQI & Snoring index & Moca-K(model 3) Adjusted R2 =0.252. F=15.572, p=0.000, Mediation effect test of Baron and Kenny : Dependent Variable Moca-K, Independent variable % N1 stage, Age, BDI, supine RDI-Model 1% N1 stage(model 1) Adjusted R2 =0.107, F=13.469, p=0.000/%N1 stage & Age(model 2) Adjusted R2 =0.157, F=10.716, p=0.000/%N1 stage & Age & BDI(model 3) Adjusted R2 =0.226, F=11.101, p=0.000 Cognitive function were affected by changes in age, waist thickness, NREM sleep stage I, depression, and sleep apnea. Poor sleep quality, increased snoring, and decreased cognitive function will increase depression. Depression have partial mediating effects about cognitive dysfunctions by age and NREM stage I.