Relationship of zinc, copper and manganese levels on bone formation that increases the risk of uterine cancer

Abstract

Due to the lack of previous studies on the impact of osteoporosis on the incidence of uterine cancer, and the rapid spread of uterine cancer in recent years all over the world, and the exact mechanism of its occurrence is not entirely clear. The study focused on the possibility of consideration of osteoporosis as a marker to uterine cancer by study the relationship between osteoporosis and uterine cancer through the measurement of both Zinc (Zn), Copper (Cu) and Manganese (Mn) which operate inside the body as antioxidation when its linked with enzymes, which affect the bone density and their impact on the incidence of uterine cancer. The study involved collecting samples from hospitals in Mosul , women without uterine cancer as the control group and divided into two groups (44 women with good health and 38 women diagnosed as osteoporosis only). And patients women also divided to the two groups did not receive any treatment (43 with uterine cancer only and 58 women with osteoporosis and uterine cancer). Each patient was evaluated clinically and then was estimated Zinc, Copper and Manganese in serum using atomic absorption spectroscopy technique as well as appreciation of both estrogen and progesterone in the serum. The results showed that osteoporosis may increase the incidence of uterine cancer through hormonal changes and the concentration of antioxidants and their impact on the bone-building and thus its impact on the amount of free radicals in the body which cause increase the likelihood of uterine cancer before and after menopause. Accordingly, the study showed that osteoporosis is a new risk factors increase the likelihood of uterine cancer. Accordingly, women should pay attention to bone health by maintaining the concentration of antioxidant mineral , which includes all of the Zinc, Copper and Manganese, which has a role in bone health and prevent fragility and early diagnosis and treatment of osteoporosis to reduce the risk of uterine cancer.