Relationship of Visceral Adiposity Index with New-Onset Hyperuricemia in Hypertensive Patients

Abstract

Background: Visceral adiposity index is a new type of indicator that accurately reflects distribution and function of visceral fat. The relation between VAI and new-onset hyperuricemia remains largely understudied. Purpose: This study sought to further investigate the prospective association between VAI and the risk of hyperuricemia by examining possible effect modifies in hypertensive patients. Methods: We enrolled 10,513 hypertensive patients with normal uric acid (UA) concentrations (<357 μmol/L (6 mg/dL)) who participated the UA Sub-study of the China Stroke Primary Prevention Trial (CSPPT). Our primary outcome was new-onset hyperuricemia, which was defined as a UA concentration ≥417 μmol/L (7 mg/dL) in men or ≥357 μmol/L (6 mg/dL) in women at the exit visit. Results: Over a median follow-up of 4.4 years, 1,642 (15.6%) participants developed new-onset hyperuricemia. When VAI was assessed as quartiles, a significantly higher risk of new-onset hyperuricemia was found in participants in quartile 4 (≥2.98; odds ratio, 1.17; 95% CI: 1.01-1.36) compared with those in quartile 1-3 (<2.98). Furthermore, we discovered that the positive relation was independent of abnormal VAI components or numbers of abnormal VAI components (all P-interactions > 0.05). Conclusion: There was a positive relationship between baseline VAI and the risk of new-onset hyperuricemia in a sample of Chinese hypertensive individuals.