Relationship of the blood flow parameters around the follicle and in vitro fertilization-embryo transfer outcome for patients with poor ovarian response

Abstract

Objective To explore the relationship between the blood flow parameters of poor ovarian response patients on human chorionic gonadotropin (hCG) injection day and the outcome of in vitro fertilization -embryo transfer (IVF-ET) cycle. Methods Patients who received IVF-ET from September 2014 to September 2015 in our hospital were seclected. The blood flow parameters around the follicle were monitored by transvaginal color Doppler ultrasound on the day of hCG injection. The relationship between the four flow parameter values including systolic maximum blood flow velocity (PSV), resistance index (RI), pulse index (PI), the late arterial systolic/diastolic peak flow velocity blood flow velocity ratio (S/D), and pregnancy outcome were were detected. Results 1) The PSV of the pregnancy group was (14.86±3.36) cm/s, and was (12.38±3.72) cm/s in non-gestation group, with statistically significant differences between the two groups (P=0.000 2). And PI, RI, S/D was not statistically significant between the two groups. 2) With the increase of PSV, and when PSV≥ 10.5 cm/s, the number of follicles with diameter≥14 mm, estrogen (E2) on hCG injection day, MⅡ rate of eggs, egg number, high-quality embryo rate and clinical pregnancy rate were significantly increased, but were not collected with age, endometrial thickness on hCG injection day and designed. the Gn used dosage, the Gn used days, infertility duration. Conclusion The quality and maturity of follicle can be evaluated comprehensively by the PSV of the surrounding blood flow parameters on hCG injection day, and the PSV has a certain value in predicting the outcome of pregnancy, while PI, RI, S/D cannot predict the pregnancy outcome well. Key words: Transvaginal doppler ultrasound; In vitro fertilization-embryo transfer (IVF-ET); Superovulation; The blood flow parameters around the follicle; Pregnancy outcomes