Abstract

Oral cancer is the fifth leading cause of cancer death in Taiwan, and the prevalence of metabolic syndrome (MS) has also increased globally. The purpose of this study was to investigate the correlations between the components of MS and oxidative stress and inflammation in patients with oral cancer based on their areca-nut-chewing habits. Two hundred patients diagnosed with oral cancer were recruited, and metabolic parameters, oxidative stress, antioxidant enzyme activities, and inflammatory markers were measured. 63% of the subjects have concomitant MS. Subjects who had an areca-nut-chewing habit had significantly higher levels of fasting glucose (p = 0.04), oxidative stress (p = 0.02), and inflammatory markers (p = 0.02) than those who never chewed. High-density lipoprotein-cholesterol level (p = 0.03) and superoxidase dismutase activity (p = 0.02) were significantly lower in individuals who had chewed or were currently chewers. Areca-nut-chewing habit was associated with the increased risks for MS and hypertriglyceridemia; the components of MS were positively correlated with oxidative stress and inflammation. In conclusion, patients with oral cancer who had an areca-nut-chewing habit exhibited higher levels of oxidative stress and inflammation, which might be related to an increased risk of MS.

Highlights

  • According to the latest cancer statistics from the American Cancer Society, Americans accounted for the estimated 30% of the new cases of oral cancer and 2% of the oralcancer-related deaths that occurred in the US in 2017 [1]

  • Patients diagnosed with oral cancer and who underwent tumor resection were recruited from the Department of Dentistry at Taichung Veterans General Hospital

  • A total of 95% of the oral cancer patients were male with a mean age of 54 years old

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Summary

Introduction

According to the latest cancer statistics from the American Cancer Society, Americans accounted for the estimated 30% of the new cases of oral cancer and 2% of the oralcancer-related deaths that occurred in the US in 2017 [1]. In addition to the carcinogenic effects of areca nut chewing, harmful relationships between this habit and metabolic syndrome (MS) [6,7,8,9], type 2 diabetes [9, 10], and cardiovascular disease [9, 11, 12] have been observed. We usually recommend that patients with oral cancer should abstain from areca nut chewing. No research has followed the status of metabolic parameters of oral cancer patients after quitting areca nut chewing

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