Relationship of Midkine in Myocardial Infarction patients and some biochemical parameters

Abstract

Objectives: This study aims to estimate the concentrations of MK, hs-CRP, TnI, AST, ALT and ALP in serum for MI in comparison to wholesome controls, in an effort to check the quantity of this impact at the pathological condition, in addition to understanding the position of MK in MI sufferers and its relationship to liver function tests and may be used as biochemical markers to decide the severity of MI in sufferers.
 Methods: The studying include the investigation of midkine (MK), High-sensitivity C-reactive protein (hs-CRP), Troponin I (TnI), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and alkaline phosphatase (ALP) levels in myocardial infarction (MI) patients. The study includes (84) samples: 34 of myocardial infarction patients (19 male and 15 female) and 50 sample of apparently healthy as control group (25 male and 25 female). Samples were collected during the period from Jan. 2021 to July 2021 from in-patients of Cardiac Surgery Center admitted at Ibn Sina Teaching Hospital and Mosul General Hospital, Mosul, Iraq with matching age ranged between 26-86 years. The clinical diagnosis in each case is made according to a cardiovascular specialist.
 Results: The results showed that there was a significant increase in MK, TnI, GOT, GPT and ALP for all studied groups (males and females) of MI patients compared with control groups, and there was no any a significant in hs-CRP. Beside of, showed significant positive correlation between MK with BMI, hs-CRP, TnI, AST, ALT and ALP in control and patients group. Whereas there were no any correlation between MK with age, in patients and control under study.
 Conclusion: The study indicated that the MK increased in patients with myocardial infarction, and it’s increased in males more than female patients, and that may act as a good markers for diagnosis of myocardial infarction disease.