Abstract
Excessive mobilization of body fat in the dairy cow is a well-known risk factor for poor fertility, metabolic problems and increased susceptibility to a variety of infectious diseases. In humans, obese patients have an enhanced production of pro-inflammatory cytokines (such as Tumor Necrosis Factor-alpha and Interleukin- 6), which has been recognized to induce a pro-inflammatory environment and facilitate oxidative damage, leading to the initiation and progression of an array of diseases. The purpose of this study was to investigate if a similar relationship exists in the dairy cow between obesity, oxidative stress, pro-inflammatory cytokines and susceptibility to disease.
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