Relationship of Body Composition Measures and Metabolic Basal Rate with Gastrointestinal Hormones in Weight Regain 5Years After Gastric Bypass.

Abstract

To assess the relationship of body composition measures and basal metabolic rate (BMR) with gastrointestinal hormones in weight regain 5years after gastric bypass. A total of 42 patients were divided into two groups: with and without weight regain 5years after gastric bypass. Hormone assessments were performed after a fasting period and at 30, 60, and 120min after the standard meal intake. Patients with no weight regain had significantly lower visceral fat (VF), lower fat body mass (FBM), and lower fat percentage (%F) in relation to the other group. In the group without weight regain, at baseline, glucose-dependent insulinotropic polypeptide (GIP) showed a negative correlation with weight and BMI and a positive correlation with BMR, skeletal muscle mass (SMM), and fat-free mass (FFM). After the standard meal, the following results were found: a negative correlation with %F, a positive correlation of glucagon-like peptide-1 (GLP-1) with FFM, and a positive correlation of GLP-2 and PYY with BMR, SMM, and FFM. In the group with weight regain, at baseline, GIP, PYY, and GLP-1 showed a negative correlation with %F. After the standard meal, PYY and GLP-1 showed a negative correlation with VF, FBM, and %F. On the other hand, GLP-2 negatively correlated with VF and FBM. It is possible to conclude that there is a different relationship of concentrations of PYY, GIP, GLP-1, and GLP-2 with body composition and BMR in patients with and without weight regain in the late gastric bypass postoperative period.