Relationship of blood level of galectin-3, C-reactive protein and the Gensini score of coronary lesions in patients with coronary artery disease

Abstract

Objective To investigate the relationship of blood level of galectin-3, C-reactive protein and the severity of coronary lesions in patients with coronary artery disease. Methods The 113 patients with coronary heart disease were divided into stable angina group (stable angina, SA), unstable angina group (unstable angina, UA) and acute myocardial infarction group (acute myocardial infarction, AMI), and the control group with 42 cases were normal in coronary angiography. There were 1st quartile group, 2nd quartile group, 3rd quartile group and 4th quartile group according to the quartile of Gensini score. The blood levels of Galectin-3 and CRP were examined, the relationship between galectin-3, CRP and the Gensini score were analyzed. Results The blood levels of Galectin-3 and CRP were significantly different in SAP, UAP, AMI groups and control group(F=19.922, 9.645, P=0.000, 0.009), and each group also had difference (P<0.01). There were significant differences in the levels of galectin-3 and CRP among different Gensini score groups(F=69.803, 4.267, P=0.000, 0.024), each group also had significant difference (P<0.05). The blood levels of galectin-3, CRP were positively correlated with Gensini score (R=0.745, 0.769, P=0.000, 0.000). Conclusions The blood levels of galectin-3 and CRP can be used as a reference index for the assessment of severity of coronary lesions in patients with coronary artery disease, has a high clinical value, and is worth to further discussion. Key words: Coronary artery disease; Galectin-3; C-reactive protein; Coronary artery