Abstract
Objective: Objective: to assess the relationship between changes in the carotid-femoral pulse wave velocity (PWVcf) with glomerular and tubular function in patients with hypertension with a high adherence to treatment. Design and method: Materials and methods: 82 hypertensive patients with a high adherence to treatment were examined (average age 50.23 ± 7.16), who were divided into 2 groups depending on PWVcf. Group 1 - 41 patients with PWVcf less than 10 m / s, Group 2 - 40 patients with PWVcf more than 10 m / s. To determine the level of CFS, all patients underwent volume sphygmopletismography. To assess the renal filtration function, the serum level of cystatin C was determined by ELISA and GFR was calculated using the CKD-EPI formula for cystatin C. Also, for the assessment of tubular renal function, the level of serum NGAL was determined by the method ELISA. Results: Results: patients in the groups did not significantly differ in age, gender, risk factors, concomitant diseases and therapy, blood pressure and lipid profile. In group 2, the NGAL level was 1.68 ± 0.83 ng/ml, which is more than in group 1 - 1.27 ± 0.57 ng/ml (p = 0.032). At the same time, the patients did not statistically significantly differ in the level of cystatin C and GFR based on cystatin C. Correlation analysis showed a direct moderate relationship between PWVcf and the level of NGAL (r = 0.31; p < 0.05) in these patients was found. Conclusions: Conclusions: in hypertensive patients with a high adherence to treatment, along with an PWVcf increase, there is a significant deterioration in tubular renal function, estimated by an increase in NGAL level. GFR with high adherence to treatment was not associated with changes in PWVcf.
Published Version
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