Relationship between vascular endothelial growth factor and dendritic cells in non-small cell lung cancer

Abstract

Vascular endothelial growth factor( VEGF) is recognized as a key factor in tumor,which can hamper dendritic cells( DC) to mature. Thus DC can secrete VEGF to induce self-dysfunction,to induce tumor cells escaping from immune surveillance. The relationship between VEGF and the DC is closely related with the differentiation,clinical stages and lymph node metastasis in non-small-cell lung carcinoma(NSCLC). It can pro-vide appropriate theoretical basis for clinical treatment of NSCLC. Key words: Vascular endothelial growth factor; Dendritic cells; Carcinoma, non-small-cell lung