Relationship between TSH and pregnancy outcomes during the first half of pregnancy in women

Abstract

A total of 352 pregnant women were selected in Affiliated Hospital of Qingdao University. Serum levels of TSH and FT4 were determined and pregnancy outcome were observed in all subjects. According to the standard of American Thyroid Association(ATA)published in 2011 and the Chinese Guideline of Gestation Thyroid Disease published in 2012, the subjects were grouped into control(0.1≤TSH≤2.5 mIU/L), observation(2.5 5.17 mIU/L)during first-trimester(T1)and control(0.2≤TSH≤3.0 mIU/L), observation(3.0 5.22 mIU/L)during second-trimester(T2). The results showed that the rupture of membranes, preterm labor, and total obstetrical adverse events in the observation group were significantly higher than those in control group during T1(all P<0.05), no statistical significance between control group and treatment group. The rupture of membrances in the observation group was significantly higher compared with control group during T2(P<0.05), no significant difference in other adverse pregnancy outcomes between these two groups. Compared with control group during T1, the proportion of adverse pregnancy outcomes in observation group during T1 was significantly increased(P<0.05). The elevated TSH is one of the risk factors for the increased incidence of adverse pregnancy outcomes at the first half of pregnancy, especially during T1. L-T4 treatment reduces the incidence of adverse pregnancy outcomes. (Chin J Endocrinol Metab, 2017, 33: 52-55) Key words: The first half of pregnancy; TSH; Pregnancy outcomes