Abstract
Introduction: Inflammatory Bowel Disease (IBD), periodontitis and Systemic Lupus Erythematous (SLE) are multifactorial diseases, one of the factors in the course of these diseases is the rs333 polymorphism in the CC chemokine receptor type five (CCR5) gene. However, the results remain contradictory. Therefore, we aimed to perform a meta-analysis evaluating the relation between this polymorphism and the aforementioned conditions. Material and Methods: A search in the literature was performed in diverse scientific and medical databases for studies published before June 22, 2020. The data were extracted from the studies and the statistical evaluation was performed by the calculations of statistical heterogeneity (I²), Odds Ratio (OR) with 95% of Confidence Intervals (CI) and publication bias. The values of P<0.05 were considered as significant for all calculations. Results: 19 articles with 21 case/control studies in 4,304 case patients and 3,492 controls were included. The meta-analysis showed a non-significant association among the rs333 polymorphism and IBD (OR = 1.05, 95% CI: 0.91-1.20, P = 0.51), periodontitis (OR = 0.86, 95% CI: 0.64-1.17, P = 0.34) or SLE (OR = 1.00, 95% CI: 0.56-1.80, P = 1.00) under the allelic model or for any other performed calculation. There were no obvious publication bias in the analyses. Conclusion: In conclusion, this current meta-analysis evidenced the non-significant relation among the rs333 polymorphism and the risk of IBD, periodontitis or SLE. Further studies are required to validate our data.
Highlights
Inflammatory Bowel Disease (IBD), periodontitis and Systemic Lupus Erythematous (SLE) are multifactorial diseases, one of the factors in the course of these diseases is the rs333 polymorphism in the CC chemokine receptor type five (CCR5) gene
The following inclusion criteria were respected to the collection process in the literature search: (1) casecontrol studies or replication genetic studies; (2) the case-patients have been diagnosed by a rigorous clinical evaluation for [I] Inflammatory Bowel Disease [27], Periodontitis [28] or Systemic Lupus Erythematosus [29]; (3) the control patients have presented healthy periodontal evaluation or non-systemic sign of autoimmune disease; (4) the genotypic frequency have been completely documented; (5) the studies have strictly included human beings; (6) the included participants have not presented cardiovascular diseases or pregnancy
The following combination of keywords was used in the search: “periodontitis or periodontal disease or chronic periodontitis or aggressive periodontitis or inflammatory bowel disease or ulcerative colitis or Crohn’s disease or systemic rs333 Polymorphism and Inflammatory Diseases: A Meta-Analysis lupus erythematosus” and “polymorphism or genetic variation” and “CCR5” and “rs333 or Δ32 deletion”
Summary
Inflammatory Bowel Disease (IBD), periodontitis and Systemic Lupus Erythematous (SLE) are multifactorial diseases, one of the factors in the course of these diseases is the rs333 polymorphism in the CC chemokine receptor type five (CCR5) gene. Inflammatory Bowel Disease (IBD), periodontitis and Systemic Lupus Erythematous (SLE) are complex, multifactorial and relevant immunological disorders in the clinical field for the contribution of environmental, genetics and epigenetics factors that contribute to their pathogeneses [1,2,3]. The main feature of IBD is the longstanding relapsing inflammation that affects various parts of gastrointestinal and it comprises two commonly diseases: the Cronh’s Disease (CD) and Ulcerative. Periodontal diseases are a group of inflammatory disorders that range the supporting structures around the teeth resulting in possible teeth loss [9]. The main feature of CP is the slow and swift progression of disease that reaches subjects with an increased mean
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