Relationship Between Status of Methyl Donor Nutrients and Malignancy Cancer Stages in Taiwanese NSCLC Patients (P24-027-19)

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ObjectivesLung cancer patients may suffer from one-carbon malnutrition due to insufficient dietary intake or one-carbon enzymes genotypic diversity. However, the correlation of one-carbon metabolites and lung cancer risk, malignant progression is still unclear. Our objective was to examine methyl donor status and tumor stages. MethodsThe cross-sectional recruited 32 non-small cell lung cancer (NSCLC) patients in National Taiwan University Hospital (NTUH), Taiwan. Nutrition, clinical pathological and biochemical data were collected. Long-term nutritional intake was evaluated by one-carbon semi-quantitative dietary frequency questionnaire, biochemical values were analyzed by Liquid chromatography–mass spectrometry (LC/MS), Tumor information was collected by department of pathology in NTUH. ResultsData revealed that marginal deficiency rate of dietary folate intake was 26.4%, over UL value (>1000mcg) was 9.4%. Energy adjusted folate, free-choline and betaine intake had significantly positive correlation (r = 0.519, r = 0.336, r = 0.388, P < 0.05); Energy adjusted folate and vitamin B12 intake had positive correlation (r = 0.184). According to TNM stages, we classified NSCLC tumor stages and found that increasing energy adjusted folate intake was significantly positive correlated with late stage (P = .001). The adjusted dietary folate in late stages was significantly higher than early stage (P < 0.05). The clinical value of plasma marginal folate deficiency rate was 12.5%, plasma marginal high of homocysteine rate was 15.6%. Plasma free-choline and betaine levels had significantly positive correlation (r = 0.495, P = 0.023). Otherwise, plasma folate and betaine, free-choline levels had negative correlation (r = −0.166, r = −0.075), and plasma folate levels had positive correlation with vitamin B12 (r = 0.353). The plasma folate levels had significantly positive correlation with energy adjusted folate intake (r = 0.464, P = 0.034). Increasing plasma folate level was positive correlated with late tumor stage (r = 0.108). ConclusionsIn summary, higher one-carbon nutrients intake status may be associated with tumor lymphatic metastasis stages of NSCLC patients. Funding SourcesMinistry of Science and Technology.