Relationship between standard automated perimetry and high‐resolution optical coherence tomography in glaucoma patients

Abstract

Abstract Purpose To determine the relationship between the main indices of standard automated perimetry (SAP) and the peripapillary retinal nerve fiber layer (RNFL) thickness measured with spectral‐domain optical coherence tomography (OCT) in patients with glaucomatous visual field defects. Methods 47 consecutive patients with open‐angle glaucoma were included in the study. Only one eye per subject was randomly selected. SAPs were performed with a Humphrey perimeter and the 24‐2 SITA standard algorithm. All of them underwent imaging with the Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany). Left eye data were converted to a right eye format. The Kolmogorov Smirnov test was applied to check that the data were normally distributed. Pearson correlations were calculated between SAP indices (mean deviation, pattern standard deviation, and visual field index) and OCT parameters Results The average visual field mean deviation was ‐6.50 dB. Mild to moderate correlations were observed between SAP indices and most OCT parameters. The strongest correlations were found between the inferior quadrant thickness and pattern standard deviation (‐0.544). Conclusion The RNFL thicknesses measured with high‐resolution OCT showed moderate correlations with SAP indices in glaucoma patients. These results may help to understand the relationship between structural and functional changes in open‐angle glaucoma.