Abstract
ln the formation of diabetic retinopathy that is an important complication of Diabetes Mellitus, ıt ıs supposed that together with high blood glucose the increasing sialic acid in Diabetes Mellitus plays an important role. ln this study, we investigated serum total sialic acid levels relate ta glysemic control, blood pressure, retinopathy and serum lipid levels in diabetic patients. Serum total sialic acid levels in the patients were found significantly higher than normal subjects (p<0.001 ). Serum sialic acid levels were especially elevated in patients with diabetic retinopathy when compared to the group without retinopathy (p<0.01 ). There were correlations between serum fructosamin levels and total serum sialic acid levels of the patients (p<0.001, p<0.05). ln the patients without retinopathy, we found high correlation between serum sialic acid levels and systolic blood pressure and erythroycte sedimantation rate (p<0.001 ), but we found a less correlation between plasma glucose and diastolic blood pressures (p<0.01 ). ln the patients with retinopathy, a high correlation between plasma glucose and serum total sialic acid levels (p<0.001), a less correlation between erythroycte sedimentation rate, systolic and diastolic blood pressure were found (p<0.01).
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