Abstract
To analyze the relationship between systemic lipid profile levels and meibomian gland dysfunction (MGD) subtype in Korea. The ophthalmic data of 95 eyes and the serum lipid profiles of 95 patients were reviewed. These factors were compared with those of the general population using data from the Korean National Health and Nutrition Examination Survey (KNHANES), which evaluated 2,917 subjects. Of these, the comparison group (1:5 ratio; n = 475) was selected using propensity score matching according to age and sex. In addition, we analyzed the relationship between serum lipid profile levels and MGD subtypes in MGD patients. The mean high-density lipoprotein (HDL) value of the MGD patients was significantly higher than that of the general population (P < 0.0001). Moreover, the mean low-density lipoprotein (LDL) levels of the MGD patients was significantly lower than that of the general population (P = 0.0002). However, the mean total cholesterol (TC), and triglyceride (TG) levels of the MGD patients were not significantly different from those of the general population (TC: P = 0.4282, TG: P = 0.5613). In addition, no serum lipid levels statistically differed among the MGD subtypes (TC: P = 0.7650, HDL: P = 0.2480, LDL: P = 0.3430, TG: P = 0.7030). A statistically significant increase in HDL and decrease in LDL concentration were observed in the MGD group, although there was no difference in any serum lipid level among the MGD subtypes.
Highlights
To analyze the relationship between systemic lipid profile levels and meibomian gland dysfunction (MGD) subtype in Korea
We stratified our patients into age brackets; 33.68% of the MGD patients were aged > 65 years, 49.47% were aged 45–64 years, and 16.84% were younger than 45 years
The mean age of the control patients in the general population selected from the Korean National Health and Nutrition Examination Survey (KNHANES) through propensity score matching (1:5) was 56.41 years ± 12.67; 28.21% were over 65 years old, 53.89% were 45–64 years of age, and 17.89% were under 45 years of age
Summary
To analyze the relationship between systemic lipid profile levels and meibomian gland dysfunction (MGD) subtype in Korea. The mean total cholesterol (TC), and triglyceride (TG) levels of the MGD patients were not significantly different from those of the general population (TC: P = 0.4282, TG: P = 0.5613). Previous studies have demonstrated that meibomian gland dysfunction (MGD) patients exhibit elevated concentrations of cholesterol esters in meibum samples compared to those of healthy c ontrols[1,2]. The propensity score of age and sex-matched control was used as an alternative to randomized controlled trial (RCT)[11,12,13] The use of this method allows for unbiased comparison of the lipid profile between MGD patients and normal control
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call