Abstract
Introduction: Irisin is a novel peptide that plays notable role in human and animal biology and physiology. It has been reported that irisin may improve insulin resistance and related disturbances. Objectives: The aim of this investigation was to assess the relationship between serum irisin, glycemic indices, and renal function in diabetic subjects. Patients and Methods: In this cross-sectional study, a total of 102 type 2 diabetes mellitus (T2DM) patients were recruited. Blood biochemical parameters, including fasting plasma sugar (FBS), glycosylated hemoglobin (HbA1C), serum uric acid (sUA), creatinine concentration and glomerular filtration rate (GFR) were measured. All statistical analysis was performed with SPSS 16.0. Results: There was a positive correlation between irisin and age (P=0.05, r=0.19) and a negative correlation between irisin and body mass index (BMI) (P=0.01, r=-0.25) was detected. There was a significant difference of serum irisin level between patients with normal and abnormal FBS too. Conclusion: In this study we found, irisin concentration was increased with age, decreased with BMI, and it was higher in subject with abnormal FBS. Thus further research is needed to provide inclusive understanding of irisin associated physiological effects and possible implications in clinical conditions.
Highlights
Irisin is a novel peptide that plays notable role in human and animal biology and physiology
Implication for health policy/practice/research/medical education: In a study on 102 type 2 diabetic patients, we found, irisin concentration was increased with age, decreased with body mass index (BMI), and it was higher in subject with abnormal fasting blood sugar (FBS)
There was a significant difference in serum irisin level between patients with normal and abnormal FBS, but there was no significant differences in irisin level between subjects with normal and abnormal other biochemical parameters
Summary
Irisin is a novel peptide that plays notable role in human and animal biology and physiology. There was a significant difference of serum irisin level between patients with normal and abnormal FBS too. Conclusion: In this study we found, irisin concentration was increased with age, decreased with BMI, and it was higher in subject with abnormal FBS. Diabetes mellitus is a complex public health concern that is related with various micro-vascular (neuropathy, nephropathy, and retinopathy) and macro-vascular (peripheral arterial disease, coronary artery disease, and stroke) complications. These complications cause vast disability, morbidity, and mortality, and even low quality of life. Researchers have shown an increased interest in association between irisin level and diseases. Boström et al demonstrated that exercise enhances levels of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) in the muscle the expression of the type I membrane precursor protein fibronectin-type
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