Relationship between serum glycated albumin, homocysteine and diabetic cardiovascular disease

Abstract

Objective To investigate the relationship between serum glycated albumin(GA), homocyste(Hcy) and diabetic cardiovascular disease. Methods A total of 358 patients with type 2 diabetes mellitus in the Metabolic Disease Hospital of Tianjin Medical University from May 2015 to May 2016 were enrolled in this study. According to their status of cardiovascular disease and symptoms, the patients were divided into diabetes with cardiovascular disease group (n=202) and diabetes without cardiovascular disease group (n=156). Another 152 healthy person were choosed as normal control group. The levels of general biochemical indexes, GA and Hcy were compared, and the receiver operating characteristic (ROC) curve analysis was used to determine the clinical diagnostic threshold for cardiovascular disease in diabetes. Results The levels of GA (F=12.863, P<0.05) and Hcy (F=9.792, P<0.05) in diabetes with cardiovascular group were significantly higher than those in diabetes without cardiovascular disease group and normal control group. And the level of GA was positively correlated with Hcy level in diabetes with cardiovascular group(r=0.946, P<0.05). The area under the ROC curve in the diagnosis of diabetic cardiovascular disease for serum GA was 0.865 2; the sensitivity was 90.38% and the specificity was 56.28%(95% CI: 0.824 2-0.906 2). The diagnostic threshold of GA was 17.36% with a maximum value of Youde index. The area under the ROC curve in the diagnosis of diabetes with cardiovascular disease for serum Hcy was 0.910 3; the sensitivity was 92.75% and the specificity was 75.89%(95% CI: 0.878 1-0.942 6). The diagnostic threshold of Hcy was 13.25 μmol/L with a maximum value of Youde index. Conclusions Serum GA and Hcy are correlated with diabetic cardiovascular disease. The combination of GA and Hcy can be used as early predictors in diabetic cardiovascular disease. Key words: Glycated albumin; Homocysteine; Diabetic cardiovascular disease; Type 2 diabetes mellitus