Clinical significant and influential factors of the glycated albumin in type-2 diabetes mellitus patients

Abstract

Objective To investigate the change of the serum glycated albumin(GA) level in diabetic inpatients and to assess its reliability as a clinical marker for short-term blood glucose level and blood glucose control of diabetic in type-2 diabetes mellitus(T2DM) patients.Methods Three hundred and one patients with T2DM,who were hospitalized in Sichuan Provincial People's Hospital endocrinology department from February 2012 to August 2012,were enrolled in the present study.The fasting plasma glucose(FPG),2 h post-prandial glucose (2hPG),1 d fingertip blood glucose spectrum mean (MBG),GA,and glycated hemoglobin (HbA1c) were measured and recheck at the 12th d of hospitalized.GA level were measured in terms of GA-1 levels.Results (1) The GA level was positively correlated with HbA1c,2hPG,MBG(β =1.585,0.395,0.744 respectively,t =3.319,2.255,2.099 respectively,P ＜ 0.01,P ＜ 0.05,P ＜ 0.05).(2) The GA level was (25.66 ± 7.35)％ at the 12th d after admission,significantly lower than that at the first day of admission ((36.91 ±8.18)％,t =14.441,P ＜0.01).(3) Compared with the 1st day,the level of GA/HbA1c was decreased significantly at the 12th day((3.91 ± 1.00)％ vs.(2.92 ± 1.45)％,t =5.845,P ＜0.01).(4) GA value was negatively correlated with body mass index (BMI) (β3 =-0.339,t =-1.887,P ＜ 0.05).Conclusion (1) GA can accurately,promptly reflect the change of glycemic level and it might serve as the clinical monitoring marker for evaluating the glucose control in T2DM.(2) BMI should be concerned when assessing GA value of DM patients. Key words: Diabetes mellitus; Glycated albumin; Body mass index