Relationship between serum chemokine expression level in lupus nephritis with long term curative effect of plasma purification

Abstract

Objective To explore the long curative effect of plasma purification treating lupus nephritis and its relationship with serum chemokine levels. Methods Thirty-two patients with lupus nephritis who underwent plasma adsorption treatment were selected as the research group at least 2 years of follow-up. Two-year recurrence rate and 24 h urine protein quantitative level were statistically analyzed. Another 30 cases of healthy persons in the same period were selected as the control group. Enzyme-linked immunosorbent method was applied to detect serum chemokine 5 (CCL5), macrophage inflammatory protein 1α(MIP-1α) macrophage inflammatory protein 1β(MIP-1β) and other chemokine levels in the 2 groups, and the relationship between serum chemokine levels with the 24 h urine protein quantitative level in patients with lupus nephritis was analyzed. Serum chemokine levels of patients with or without lupus nephritis recurrence were compared, and the relationship between serum chemokine level with its recurrence and the value of serum chemokine level predicting the recurrence were analyzed. Results Compared with control group, serum CCL5, MIP-1α, MIP-1β and other chemokine and 24 h urine protein quantitative level of the research group before treatment were elevated (P<0.05). Compared with before treatment, serum chemokine level of the research group after treatment and during the follow-up period were lower (P<0.05). Two-year follow-up recurrence rate of the research group was 68.75%, and before and after treatment and follow-up period serum chemokine levels of patients with lupus nephritis recurrence were higher than that of patients without lupus nephritis recurrence (P<0.05). Serum CCL5, MIP-1α, MIP-1β of patients with lupus nephritis and had plasma adsorption treatment were closely related to the 24 h urine protein quantitative level and recurrence (P<0.05). Value of before and after treatment serum chemokine levels of patients with lupus nephritis and had plasma adsorption treatment singly and unitedly predicting the recurrence was good, of which value of after treatment serum chemokine level unitedly predicting the recurrence was the best. Conclusions Serum chemokine levels of patients with lupus nephritis are obviously associated with the long-term curative effect, and the value of predicting the recurrence is good, therefore, long curative effect of serum chemokine levels may be reference index in assessment of the long-term curative effect. Key words: Lupus Nephritis; Chemotactic Factors