Relationship between serum adipocyte fatty acid binding protein and maternal complications in gestational diabetes mellitus pregnant women with satisfactory glucose control

Abstract

Objective To investigate the relationship between serum adipocyte fatty acid binding protein(FABP4), insulin resistance and maternal complications in patients with gestational diabetes mellitus(GDM) with satisfactory glucose control. Methods 60 cases of pregnancy between 24 and 28 weeks of OGTT diagnosed GDM pregnant women were selected.30 cases with satisfactory blood sugar control were selected as satisfactory blood sugar control group, 30 cases with unsatisfied blood sugar control were selected as unsatisfied blood glucose control group.Healthy control group was selected from 24 to 28 weeks of healthy pregnancy in 30 patients.Fasting serum FABP4, fasting blood glucose(FPG) and fasting insulin(FINS) were measured in three groups of pregnant women after 24 to 28 weeks and pregnant term.To calculate the insulin resistance index(HOMA-IR) of the steady state model, and record and observe the complications of the three groups. Results In the satisfactory blood glucose control group, the incidence rates of pregnant hypertensive disorders, excessive amniotic fluid, premature rupture of membranes, postpartum hemorrhage, cesarean section, macrosomia, neonatal asphyxia, neonatal hypoglycemia, hyperbilirubinemia of newborn were 10.0%, 6.7%, 13.3%, 6.7%, 23.3%, 16.7%, 10.0%, 16.7%, 10.0%, which were significantly lower than those in the unsatisfied blood glucose control group (23.3%, 20.0%, 23.3%, 16.7%, 33.3%, 33.3%, 20.0%, 30.0%, 36.7%), the two groups had significant differences(χ2=4.33, 6.12, 6.01, 3.97, 7.41, 5.46, 10.02, 4.79, 9.22, all P 0.05). Pregnant 24~28 weeks, FABP4, FINS, FPG and HOMA-IR of the satisfactory blood glucose control group were (1.78±0.33)ng/mL, (12.35±0.48)mIU/L, (5.51±0.96)mmol/L, (3.88±0.55), which of the unsatisfied blood glucose control group were (2.36±0.08)ng/mL, (13.92±1.17)mIU/L, (5.46±0.74)mmol/L, (3.95±1.17), the differences between the two groups were not statistically significant(all P>0.05), and compared with the healthy control group, the differences were statistically significant(t=15.32, 10.36, 11.54, 7.34, all P 0.05). Conclusion With the control of blood glucose levels, decreased in patients with GDM FABP4, fasting blood glucose, glycosylated hemoglobin level, but high insulin resistance still persists and glycemic control satisfaction does not completely reduced the occurrence of the complications in both mothers and neonates. Key words: Adipocyte fatty acid binding protein; Gestational diabetes mellitus; Pregnancy outcome