Relationship between schizophrenia and changes in the expression of the long non-coding RNAs Meg3, Miat, Neat1 and Neat2

Abstract

Schizophrenia (SZ) is a complex disease caused by multiple factors. The development of the disease is mediated by a number of neural growth and development factors, suggesting that extensive changes in nerve structure and abnormal expression of genes in some important signalling pathways occur. Based on accumulating evidence, long non-coding RNAs (lncRNAs) play a crucial role in regulating neural diseases, including SZ. In the current study, we used mouse models of methamphetamine (METH) - and MK801-induced SZ to investigate changes in the expression of four lncRNAs (Meg3, Miat, Neat1 and Neat2) in the prefrontal cortex (PFC). Miat and Neat2 expression was significantly decreased in the PFC of the SZ model mice, regardless of whether the disease was induced by MK801 or METH. We further measured the levels of these lncRNAs in the peripheral blood (PB) collected from treated and untreated patients with SZ and from healthy controls. Neat1 and Neat2 levels were significantly decreased in the PB of untreated patients with SZ, but the trends in the expression of these lncRNAs nearly reached a normal level in treated patients with SZ. In conclusion, Neat2 and Miat may function as important regulators of SZ. Our findings provide important clues for new targets of lncRNAs that are involved in SZ.