Abstract
Objective Asthma and sleep-related breathing disorders (SRBD) are common chronic respiratory diseases in children. The relationship between asthma and SRDB is bidirectional. However, only a few studies have analyzed the relationship between asthma control status and risk of SRBD. The aim of this study was to evaluate the relationship between asthma control and SRBD and further assess the relationship between therapy/atopy/lung function of children with asthma and SRBD. Methods A total of 209 children aged 3–16 years were enrolled in this study. Pediatric sleep questionnaire (PSQ) scores were used to identify children at high risk of developing SRBD. Data on asthma control status, therapy, allergy, lung function, and exhaled nitric oxide were collected. Results A significantly higher risk of SRBD was found among children with poorly controlled asthma (34.25% vs. 13.97%, P < 0.01) and allergic rhinitis (AR) (34.29% vs. 13.92%, P < 0.01) than among children with well-controlled asthma and AR. The prevalence of SRBD was also significantly higher in asthmatic children with obesity than that with just obesity (42.11% vs. 20.00%, P < 0.05). Multiple logistic regression analysis showed that poorly controlled asthma (OR, 2.746 (95% CI, 1.215–6.209); P < 0.05) and poorly controlled AR (OR, 3.284 (95% CI, 1.430–7.544); P < 0.01) increased the odds of having SRBD. Conclusion Poorly controlled asthma and AR increase the risk of SRBD. A routine check of the level of asthma control and appropriate use of medication for AR are important because of their influence on SRBD.
Highlights
Asthma is a serious global health problem that affects 2.4–37.6% of the population across various countries [1]
Out of the 38 excluded children, 8 had chronic conditions other than atopic diseases, 17 were excluded because they were younger than 3 years old or older than 16 years old, 6 were excluded because of missing values in the Pediatric sleep questionnaire (PSQ), and 7 were excluded because their parents were unwilling to participate in the study
We evaluated the usage of nasal steroids and found that only 4.03% of children with allergic rhinitis (AR) use nasal steroids regularly; we did not find a significant difference between the children with and without sleep-related breathing disorders (SRBD). e small sample size may be responsible for the absence of a relationship between nasal steroids and the prevalence SRBD
Summary
Asthma and sleep-related breathing disorders (SRBD) are common chronic respiratory diseases in children. e relationship between asthma and SRDB is bidirectional. Only a few studies have analyzed the relationship between asthma control status and risk of SRBD. E aim of this study was to evaluate the relationship between asthma control and SRBD and further assess the relationship between therapy/atopy/lung function of children with asthma and SRBD. Pediatric sleep questionnaire (PSQ) scores were used to identify children at high risk of developing SRBD. A significantly higher risk of SRBD was found among children with poorly controlled asthma (34.25% vs 13.97%, P < 0.01) and allergic rhinitis (AR) (34.29% vs 13.92%, P < 0.01) than among children with well-controlled asthma and AR. E prevalence of SRBD was significantly higher in asthmatic children with obesity than that with just obesity (42.11% vs 20.00%, P < 0.05). Controlled asthma and AR increase the risk of SRBD. A routine check of the level of asthma control and appropriate use of medication for AR are important because of their influence on SRBD
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