Relationship between perimenopausal women's depression and female hormone levels

Abstract

Listen

Translate article

Objective To explore the correlations between serum estralio(E2),testosterone(T)levels and perimenopause depression.To find out relationships between sex hormones and vascular symptoms.Methods We collected 40 women with perimenopausal depression as case group and 40 healthy women as control group. All the subjects were assigned to six groups: menopausal transtion period case and control,postmenopausal case and control,subgroup with vascular symptoms and subgroup without vascular symptoms.Electrochemiluminescence immunoassay (ECLIA) was used to measure the levels of the serum E2 and T. Results ①The level of E2 in case group was significantly lower than that in control group(P<0.01),and had negative correlation with HAMD scales(P<0.01);In both the menopausal transition period and the postmenopause period, the level of E2 in case group was lower than that in the matched control group (P<0.05,P<0.01).②The level of T in case group was significantly higher than that in control group(P<0.01), and had the same finding between menopausal transition period'case and control(P<0.01),but had no significant difference between postmenopause'case and control (P＞0.05) .Furthermore, no association could be detected between the level of T and HAMD scales in case group(P＞0.05);③The E2/T in case group and control group had significant differences(P<0.01);④The level of T in subgroup with vascular symptoms was higher than that in subgroup without vascular symptoms(P<0.01),but the difference about E2 between the two subgroups was not statistically signifcant(P＞0.05). Conclusions ①The level of Serum E2 is a protective factor of depression;②What the real relationships between the T level and perimenopausal depression is uncertain;③The imbalance of the ratios of every sex hormones,and the dynamic equilibrium in human body being broken,can cause depression;④The higher level of serum T, not lower level of serum E2, may be related to vascular symptoms in perimenopause. Key words: Depression ; Perimenopausal ; Testosterone ; Estradiol ; Vascular symptoms ;