Relationship between PatientÂ’s Demographics and Stone Composition in Men and Women

Abstract

Purpose: To detect the differences in age, weight and height between three major stone groups. Materials and Methods: We retrospectively reviewed all patients with a diagnosis of nephrolithiasis in a large healthcare network from January 2000 to July 2014, for whom information on stone composition, age, sex, weight and height was available. Patients less than 18 years were excluded. Patients were characterized by gender and the major component of their stone analysis. We used Wilcoxon rank-sum test for continuous variables to detect the significant differences and multiple logistic regression analysis to evaluate the relative risk between stone groups. Results: 14,961 adult patients were identified. The Distribution of pure (≥ 90%) calcium oxalate, phosphate and uric acid stones in men, was (71%), (7%) and (22%) while in women it was (65%), (19%) and (16%) respectively. Males with calcium oxalate stones were taller than those with calcium phosphate by 2 cm (p=0.0006). Women with calcium phosphate stones were younger than those with calcium oxalate stones by 5 years (p=0.0001). Conclusions: Calcium phosphate stone composition is associated with a shorter stature in men and younger age in women in relation to those with calcium oxalate stones.