Relationship between obesity, physical activity, sleeping hours and red blood cell parameters in adult Sudanese population

Kamal Mohammad Awad,Asim Alaaeldin Osman,Ibrahim Abdelrhim Ali,Amir Ali Bashir,Elmutaz Hussien Taha,Abdelmuhsin Hussien Mohamed,Abdarahim Alborai Abeadalla,Omer Abdel Aziz Musa

doi:10.23921/amp.2019v3i2.49097

Abstract

Ideal body weight with proper physical activity and good sleep are essential parameters for good quality of life. This study is concerned with assessing the association of general obesity, physical activity and sleeping hours with hemoglobin (Hb) concentration and red blood cell (RBC) parameters in healthy adults in Sudan. In this cross sectional study, 1086 healthy adults between 20 and 60 years were included out of which 275 were males and 811 were females. A complete blood count (CBC) was performed for Hb, RBC count, PCV, MCH and MCHC using Sysmex KX-21 automated hematology analyzer. The median and 95 percentile (2.5th to 97.5th) range values for Hb and RBC count in underweight were 13.0 (Range: 9.6-16.7) g/dl and 4.6 (Range: 3.6-5.8) ×1000/µL respectively, while Hb and RBC count in obese were 13.1 (Range: 10.4-17.0) g/dl and 4.6 (Range: 3.7-5.9) ×1000/µL respectively, with no significant difference. The RBC count (p=0.004) and Hb (p≤0.001) were significantly high in physically active compared to physically inactive participants; whereas the hemoglobin concentration (p=0.047), red blood cells (p=0.007) and hematocrit (p≤0.001) values were significantly low in long-term sleep compared to normal sleeping hours. In conclusion, there were no significant differences in hemoglobin concentration, RBC count, PCV, MCH and MCHC between under weight, normal weight, overweight and obese persons. Increased physical activity was associated with higher Hb levels and RBC counts, while long-term sleep showed lower Hb and RBCs.

Highlights

Enlarged adipose tissue increases the risk of diabetes, hypertension, cardiovascular disease and respiratory disorders
The red blood cell (RBC) count, hemoglobin (Hb) and hematocrit (HCT) and blood indices showed no significant differences with different body mass index categories (Table 1 and Table 2)
Our results showed that the hemoglobin concentration, red blood cells and hematocrit were significantly low in long-term sleep compared with normal sleeping hours (Table 7; Figure 4 and Figure 5)

Summary

Introduction

Enlarged adipose tissue increases the risk of diabetes, hypertension, cardiovascular disease and respiratory disorders. It effects iron status in the body [1]. Obesity is associated with subclinical inflammation which might contribute to development of anemia. Severe weight loss is associated with significant decrease in C-reactive protein (CRP) which is the main acute phase protein and a sensitive marker of systemic inflammation. Several studies demonstrated that the anemia is directly associated with general obesity and physical inactivity [3,4,5]

Methods

Results

Conclusion