Abstract
AbstractBackgroundIn this study, we identified whether amyloid‐β (Aβ) moderates the relationship between the plasma level of neurofilament light chain (NfL) and the change of cognition or brain volume.MethodOf 723 non‐demented participants from the Alzheimer’s Disease Neuroimaging Initiative (mean age 72.1), 341 (47.2%) had cerebral Aβ deposition (Aβ [+]) and 382 (52.8%) had not (Aβ [‐]) determined by Florbetapir PET. Longitudinal changes of cognition was assessed by Alzheimer’s Disease Assessment Scale‐Cognitive Subscale (ADAS‐Cog) score, and hippocampal and white matter hyperintensity volume by brain MRI.ResultAβ status moderated the relationship between plasma NfL and ADAS‐Cog score (beta = 0.002, P = 0.029), hippocampal volume (beta = ‐0.073, P = 0.004), and white matter hyperintensity volume (beta = 0.673, P = 0.048).ConclusionThese results suggest the possible interactive effect between plasma NfL and brain Aβ on the longitudinal cognition and brain structure.
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