Relationship between molecular genetic and clinical and morphological parameters in patients with stage I–IIIA non-small cell lung cancer

Abstract

Purpose: to study the molecular genetic landscape of the Russian cohort of patients with stage I–IIIA non-small cell lung cancer, to identify correlations between molecular genetic and clinical and morphological parameters of the tumor. Materials and methods: routine pathological examination and targeted sequencing of tumor material (and paired material of normal lung tissue) in 90 patients diagnosed with non-small cell lung cancer. Collection of clinical information. Statistical processing of the obtained material using the SPSS Statistics 23.0 program, based on the collected database. Descriptive statistics methods were used to analyze the socio-demographic and clinical characteristics of patients. Results: data were obtained on the frequency of occurrence of somatic mutations included in the study panel among patients of the Russian population, the correlation between clinical and morphological (stage, gender, age, histological subtype) and genetic parameters of the tumor was studied. Conclusion: An in-depth study of the genetic profile in patients with localized NSCLC using the Next generation sequencing (NGS) method allows us to determine the mutational landscape of this group of patients in more detail. More detailed, per-exon sequencing makes it possible to more accurately determine the clinical significance of the identified mutations, which improves diagnosis and makes subsequent treatment tactics more precise.