Abstract
ObjectiveTo analyze the association between −1082A/G polymorphism in interleukin-10 (IL-10) gene and ischemic stroke (IS) risk by meta-analysis.MethodsWe carried out a systematic electronic search in PubMed, BIOSIS Previews, Science Direct, Chinese National Knowledge Infrastructure, Chinese Biomedical Database, Weipu database and WANGFANG Database. Pooled odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated to assess the strength of the association.Results7 studies were included. There was no significant association between IL-10 −1082A/G polymorphism and IS risk under all genetic models in overall estimates (A vs. G: OR = 1.23,95%CI = 0.85–1.79;AA vs. GG: OR = 1.01,95%CI = 0.47–2.19; AG vs. GG: OR = 0.76, 95%CI = 0.38–1.55; AA+AG vs. GG: OR = 0.89,95%CI = 0.46–1.73; AA vs. AG+GG: OR = 1.39, 95%CI = 0.91–2.13). Similarly, no associations were found in subgroup analysis based on ethnicity and source of controls. However, removing the study deviating from Hardy–Weinberg equilibrium (HWE) produced statistically significant associations for overall estimates under recessive model(AA VS. AG+GG OR 1.58, 95% CI 1.04–2.42) and among Asians in all genetic models (A VS.G OR 1.64, 95% CI 1.07–2.53; AA vs. GG OR1.91, 95% CI 1.31–2.80; AG vs. GG OR1.44, 95% CI 1.09–1.91; AA+AG vs. GG OR 1.54, 95% CI 1.18–2.01;AA VS. AG+GG OR 1.79, 95% CI 1.07–3.00). Even after Bonferroni correction, the associations were observed still significantly in Asians under the two models (AA vs. GG OR1.91, 95% CI 1.31–2.80, P = 0.0008; AA+AG vs. GG OR 1.54, 95% CI 1.18–2.01, P = 0.001).ConclusionThis meta-analysis indicates that IL10 −1082 A/G polymorphism is associated with IS susceptibility in Asians and the −1082 A allele may increase risk of IS in Asians. Considering the sample size is small and between-study heterogeneity is remarkable, more studies with subtle design are warranted in future.
Highlights
Ischemic stroke (IS) is a major cause of adult disability and death in the world[1], which is a heterogeneous multifactorial disease associated with genetic and environmental factors[2]
There was no significant association between interleukin 210 (IL-10) 21082A/G polymorphism and IS risk under all genetic models in overall estimates (A vs. G: odds ratios (ORs) = 1.23,95% confidence intervals (95%confidence interval (CI)) = 0.85–1.79;AA vs. GG: OR = 1.01,95%CI = 0.47–2.19; AG vs. GG: OR = 0.76, 95%CI = 0.38–1.55; AA+AG vs. GG: OR = 0.89,95%CI = 0.46–1.73; AA vs. AG+GG: OR = 1.39, 95%CI = 0.91– 2.13)
This meta-analysis indicates that IL10 21082 A/G polymorphism is associated with IS susceptibility in Asians and the 21082 A allele may increase risk of IS in Asians
Summary
Ischemic stroke (IS) is a major cause of adult disability and death in the world[1], which is a heterogeneous multifactorial disease associated with genetic and environmental factors[2]. During the past few years, more and more evidence showed that inflammatory molecules and the genetic variation of the genes which encoded these inflammatory cytokines might take part in the pathogenesis of stroke [3]. Several candidate genes of inflammatory cytokines are implicated in the pathogenesis of IS, one of which is interleukin 210 (IL-10). IL-10(Gene ID: 3586) is a multifunctional cytokine with antiinflammatory properties, which has been showed involving in the inflammatory process of IS[5]. The human IL-10 gene is located on chromosome 1q31-32, in which some polymorphisms have been found in the promoter region, such as, 21082A/G (rs1800896), 2592C/A (rs1800872) and 2829C/T (rs1800871) [6]. The 21082A/G ( named as 21087A/G in some studies) polymorphism could affect IL-10 production [7]. It is believed that the A/G substitution is relevant to low/high amount of IL-10 secretion, respectively [7]
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