Relationship between insulin resistance and serum ferritin, blood lipids level in patients with gestational diabetes mellitus

Abstract

Objective To explore the relationship between insluin resistance(IR)and plasma fibrinogen, blood lipids levels in patients with gestational diabetes mellitus(GMD). Methods Totally 127cases pregnant women in their 24-28 gestational weeks were divided into GDM group(n=37), gestational impaired glucose tolerance test(GIGT) group(n=30)and normal glucose tolerance(NGT)group(n=60)based on the American Diabetes Association (ADA)2009 GDM diagnostic standards.All selected cases's height, weight, fasting blood glucose(FBG), fasting insulin(FIN), blood lipids and fibrinogen(FIB)level were tested, and their body mass index(BMI)and IRindex(HOMA-IR)were calculated. Results During the mid-trimester, the levels of BMI,FIB,HOMA-IR,FBG,FIN, triglyceride(TG),cholesterol(TC),low density lipoprotein-cholesterol(LDL-C)in the GDM group were significantly higher than the GIGT and NGT groups. However, high density lipoprotein-cholesterol(HDL-C)was significantly lower(F=69.29,98.15,70.32、141.43、61.92,106.06,157.06,90.59,25.25,all P<0.01).FIB was significantly positively correlated with BMI,FBG,FIN,HOMA-IR,TC,TG,LDL-C(r=0.441,0.682,0.506,0.599,0.493,0.591,0.633,all P<0.01), and negatively correlated with HDL-C(r=-0.419,P<0.01). Multiple stepwise regression analysis indicated that BMI,LDL-C,FBG and TG were independent risk factors affecting FIB(t=7.683,2.678,3.184,3.844,all P<0.01);FIB,BMI,FBG,FIN and TC were independent risk factors influencing HOMA-IR(t=68.784,3.201,29.702,58.100,2.904,all P<0.01). Conclusion Pregnant women have IR and blood lipid disorders during the mid-trimester, the overexpression of FIB is closely related to it. Key words: Gestational diabetes mellitus; Insulin resistance; Ferritin; Blood lipid