Abstract
Background: Several studies illustrated that IL-23/Th17 axis could be an important pro-inflammatory pathway in atherosclerosis. As a key element in this inflammatory mechanism, interleukin-23 receptor (IL-23R) may play a critical role in the pathological process of atherosclerosis. Single nucleotide polymorphisms (SNPs) in IL-23R have recently been consistently found to be associated with atherosclerosis diseases. However, its association with acute coronary syndrome (ACS) is still indistinct. Here, we discussed whether genetic polymorphisms in IL-23R (rs11209026 G/A) were associated with susceptibility to ACS. Methods: Among 160 patients with ACS, it includes 80 patients with unstable angina pectoris (UAP), 80 patients with myocardial infarction (MI), and 80 control subjects were selected randomly. The polymorphisms of IL-23R (rs11209026 G/A) were analyzed by the Sanger method. Results: Data showed that percentages of rs11209026 AG genotypes were significantly lower in ACS group (including: UAP and MI) than in controls (odds ratio [OR]= 0.324, 95% confidence interval [CI]: 0.148 - 0.712, p = 0.005; OR = 0.351, 95% CI: 0.135 - 0.910, p = 0.031; OR = 0.303, 95% CI: 0.112 - 0.817, p = 0.018, respectively). Furthermore, there was no correlation between rs11209026 G/A SNP and dyslipidemia-associated ACS. Conclusions: The variant of the rs11209026 polymorphism in IL-23R gene might decrease the risk of ACS, and these data suggest that AG genotype of the rs11209026 G/A polymorphism may act as a protective factor for acute coronary syndrome and subtype of ACS.
Highlights
As a major public health issue, coronary heart disease has been the leading cause of mortality and morbidity worldwide [1]
The variant of the rs11209026 polymorphism in interleukin-23 receptor (IL-23R) gene might decrease the risk of ACS, and these data suggest that AG genotype of the rs11209026 G/A polymorphism may act as a protective factor for acute coronary syndrome and subtype of ACS
In order to survey whether rs11209026 G/A Single nucleotide polymorphisms (SNPs) is independently correlated with dyslipidemia, we investigated this polymorphism with dyslipidemia in the normal coronary arteries group
Summary
As a major public health issue, coronary heart disease (a clinical form of coronary atherosclerosis) has been the leading cause of mortality and morbidity worldwide [1]. Acute coronary syndrome (ACS) is a clinical syndrome of coronary heart disease (CHD); it is a progressive inflammatory disease of the coronary arterial vascular wall and remains among high risk of mortality, which includes unstable angina pectoris (UAP), non-ST elevation myocardial infarction (NSTEMI), and ST elevation myocardial infarction (STEMI) [1] [2]. Atherosclerotic plaque rupture is the key mechanism of ACS. Inflammation plays an important role in the rupture of the vulnerable plaques by regulating the stability of atherosclerotic plaque, as well as the plaque’s thrombogenic potential [3]. As a key element in this inflammatory mechanism, interleukin-23 receptor (IL-23R) may play a critical role in the pathological process of atherosclerosis. Single nucleotide polymorphisms (SNPs) in IL-23R have recently been consistently found to be associated with atherosclerosis diseases. Conclusions: The variant of the rs11209026 polymorphism in IL-23R gene might decrease the risk of ACS, and these data suggest that AG genotype of the rs11209026 G/A polymorphism may act as a protective factor for acute coronary syndrome and subtype of ACS
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