Abstract
BackgroundAs a key element in the T-helper 17 (Th17) cell-mediated inflammatory process, interleukin-23 receptor (IL-23R) plays a crucial role in the pathogenesis of cancer. Single nucleotide polymorphisms (SNPs) in IL-23R have been frequently studied in several previous case-control cancer studies, but its association with esophageal squamous cell carcinoma (ESCC) in Chinese population has not been investigated. This study examined whether genetic polymorphisms in IL-23R were associated with ESCC susceptibility.MethodsA hospital-based case-control study of 684 ESCC patients and 1064 healthy controls was performed to assess the association between four previous reported IL-23R genotypes (rs6682925, rs6683039, rs1884444 and rs10889677) and ESCC risk. The results revealed that the C allele of the rs10889677A>C polymorphism in the 3′UTR of IL-23R gene was inversely associated with the risk of ESCC.ResultsThe rs10889677AC genotype had significantly decreased cancer risk (odds ratio [OR] = 0.85, 95% confidence interval [CI] = 0.69–1.01) compared to subjects homozygous carriers of rs10889677AA, the risk decreased even further in those carrying rs10889677CC genotype (OR = 0.64, 95% CI = 0.44–0.93). No significant association was found between the other three polymorphisms and the risk of ESCC.ConclusionThese findings indicated that rs10889677A>C polymorphism in IL-23R may play a protective role in mediating the risk of ESCC.
Highlights
Esophageal carcinoma is the eighth most common human cancer and the sixth high cancer mortality [1] of which the 5-years survival rate for all stages combined is less than 20% [2]
Esophageal squamous cell carcinoma (SCC) and esophageal adenocarcinoma (EAC) are the two primary types of esophageal carcinoma and they account for more than 95% of all cases of esophageal carcinoma
interleukin-23 receptor (IL-23R) plays an important role in the initiating, maintaining and accelerating the IL-23/IL-17 inflammatory signal transduction pathway [10]
Summary
Esophageal carcinoma is the eighth most common human cancer and the sixth high cancer mortality [1] of which the 5-years survival rate for all stages combined is less than 20% [2]. The fact that a small portion of exposed individuals develop esophageal carcinoma suggests that genetic susceptibility plays a more important role in an individual’s risk of esophageal carcinoma. Previous studies have indicated that IL23R can promote tumor growth and may decrease immunosurveillance by CD8+ T-cells [11]. These findings suggest that IL-23R may play an important role in cancer development and progression. As a key element in the T-helper 17 (Th17) cell-mediated inflammatory process, interleukin-23 receptor (IL-23R) plays a crucial role in the pathogenesis of cancer. Single nucleotide polymorphisms (SNPs) in IL-23R have been frequently studied in several previous case-control cancer studies, but its association with esophageal squamous cell carcinoma (ESCC) in Chinese population has not been investigated. This study examined whether genetic polymorphisms in IL-23R were associated with ESCC susceptibility
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
