Relationship between Hypercoagulable State and Circulating Tumor Cells in Peripheral Blood, Pathological Characteristics, and Prognosis of Lung Cancer Patients.

Linqian Wu,Songwen Tan,Tongshan Hu,Yanhua Jiao,Liling Guo

doi:10.1155/2021/5732222

Abstract

Objective To analyze the relationship between hypercoagulable state and circulating tumor cells (CTCs) in peripheral blood, pathological characteristics, and prognosis of lung cancer patients. Method A total of 148 patients with primary lung cancer diagnosed and treated in our hospital from January 2017 to January 2019 were selected as the research objects. According to the CTC test results, the patients were divided into CTC-positive group and CTC-negative group. Also, the coagulation index of patients was tested. According to the blood coagulation index test results, patients were divided into hypercoagulable group and non-hypercoagulable group. The relationship between hypercoagulable state and pathological characteristics of lung cancer patients was analyzed by single factor analysis and multiple logistic regression model. Kaplan–Meier survival curve was applied to analyze the relationship between hypercoagulable state and the prognosis of lung cancer patients. Results The platelets (PLTs), fibrinogen (FIB), D-dimer (D-D), and prothrombin time (PT) in CTC-positive group were significantly higher than those in CTC-negative group. There was no significant relationship between the patient's gender, smoking history, pathological type, and the hypercoagulable state of the patients. The proportion of patients aged 60 years or older, with TMN stage III or IV and lymph node metastasis, in the hypercoagulable group was significantly higher than that in the non-hypercoagulable group. Logistic regression analysis showed that there was an independent relationship between the patient's age, lymph node metastasis, and hypercoagulable state. As of January 2020, among the 148 patients with lung cancer follow-up, 5 patients were lost and 52 died. The median survival time of patients in the hypercoagulable group was 82 weeks, which was significantly lower than the 104 weeks in the nonhypercoagulable group. Conclusion There is a certain relationship between hypercoagulable state and CTC positive in lung cancer patients. There is an independent relationship between the patient's age, lymph node metastasis, and the hypercoagulable state. The median survival time of patients in the hypercoagulable group was significantly lower than that in the non-hypercoagulable group.

Highlights

Lung cancer is a common malignant tumor that has the characteristics of high incidence, high mortality, and many complications, which seriously endangers human health and safety. rombosis is one of the common complications of lung cancer, and hypercoagulable state is the direct factor of thrombosis [1, 2]
Comparison on Clinical Characteristics of Patients in the Hypercoagulability Group and Non-Hypercoagulability Group. e results of the analysis showed that the gender, smoking history, and type of pathology of patients were not significantly related to the patients hypercoagulable state
About 90% of patients with malignant tumors have a hypercoagulable state of blood. e hypercoagulable state is mostly caused by procoagulant factors released by tumor cells, an increase in the number of activated platelets, and cytokines released by macrophages [6, 7]

Summary

Introduction

Lung cancer is a common malignant tumor that has the characteristics of high incidence, high mortality, and many complications, which seriously endangers human health and safety. rombosis is one of the common complications of lung cancer, and hypercoagulable state is the direct factor of thrombosis [1, 2]. Lung cancer is a common malignant tumor that has the characteristics of high incidence, high mortality, and many complications, which seriously endangers human health and safety. Rombosis is one of the common complications of lung cancer, and hypercoagulable state is the direct factor of thrombosis [1, 2]. E cellular active factors within human body cause inflammatory response or platelet (PLT) function change, which in turn activates prothrombins that lead to blood hypercoagulation [3, 4]. E hypercoagulable state promotes tumor development and is an important factor of thromboembolic disease. We analyzed the relationship between hypercoagulable state and CTC in peripheral blood, clinicopathological characteristics, and prognosis, with the hope to provide clinical guidance on the treatment of hypercoagulable state in lung cancer patients. We analyzed the relationship between hypercoagulable state and CTC in peripheral blood, clinicopathological characteristics, and prognosis, with the hope to provide clinical guidance on the treatment of hypercoagulable state in lung cancer patients. e details of the study are reported as follows

Methods

Results

Conclusion