Abstract

人乳头状瘤病毒(HPV)是宫颈癌的重要病因,HPV感染后,宫颈上皮组织从增生、宫颈上皮内瘤变(CIN)到浸润癌是一个多阶段的过程.此过程中HPV的存在形式往往由宿主基因组外的游离形式演变成基因组内的整合形式,整合现象被认为是CIN演变的早期事件[1],有的资料仅显示在CIN 3级及浸润癌中检出整合现象[2-3],还有研究者对HPV整合的作用提出疑问[4]。

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