Abstract
Objective To investigate the differences of the plasma homocysteine （Hcy） between the patients with acute cerebral infarction and the normal controls, and the relationship between the levels of plasma Hcy and folic acid, vitamin B12 and lipids, and the relationship between clinical symptoms in patients with acute cerebral infarction. Methods A total of 91 patients with first-ever acute cerebral infarction and 100 controls without cerebrovascular accident were included. ]heir ratio factors such as age, sex, hypertension and diabetes did not have significant differences. Enzymatic cycling was used to detect plasma Hcy levels. Chemiluminescence was use to detect folic acid and vitamin B12 levels. Biochemical analyzer was used to measure lipid levels. The patients with acute cerebral infarction were evaluated by the National Institutes of Health Stroke Scale （NIHSS）. Results qhe plasma Hcy level was significant higher in the acute cerebral infarction group than that in the control group （21.22 - 7.29μmol/L vs. 13.19 ± 2. 13 p, mol/L） （P 〈 0.05）; the plasma Hcy level in the acute cerebral infarction group was significantly negatively correlated with folic acid （r = - 0.307, P 〈0.05） and vitamin B12 （r = - 0. 270, P 〈 0.05）. It was significantly positively correlated with low-density lipoprotein （r = 0. 282, P 〈 0.05）, and it was significantly negatively correlated with high-density lipoprotein （r = - 0.219, P 〈 0.05）. The mean value of the plasma Hcy in acute cerebral infarction group increased with the increase of NIHSS scores. Conclusions Hyperhomocysteinemia is an independent risk factor for acute cerebral infarction. The levels of folic acid and vitamin B12 decreased with the increase of Hcy levels. The higher the Hcy levels, the more serious the clinical symptoms are. Hcy may increase the risk of ischemic cerebrovascular disease by influencing the lipid metabolism. Key words: brain infarction; homocysteine; folio acid; vitamin B12; hyperlipidemias
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