Relationship between expression of glucose transporter 1 and clinicopathological features and prognosis of patients with gastric cancer: a Meta-analysis

Abstract

Objective To investigate the expression of glucose transporters 1 (GLUT-1) in gastric cancer and its relation with clinicopathological characteristics and prognosis. Methods PubMed, Web of Science, EMbase, Cochrane Library, WanFang Databases and China National Knowledge Internet (CNKI) were used to search literatures about GLUT-1 and gastric cancer. From the day of establishment to May 15, 2017, according to the inclusion and exclusion criteria, 2 researchers independently screened studies, extracted data and assessed quality of the included studies. Effect value and 95% CI was calculated respectively. Then Meta-analysis was conducted by using RevMan5.3 software. Results A total of 11 articles were enrolled, including 1 714 cases in the gastric cancer group and 431 cases in the normal gastric mucosa group. The results of Meta-analysis showed that GLUT-1 expression was higher in the gastric cancer group than that in the normal group, and there was a significant difference (OR= 24.23, 95% CI 11.86-49.51, P 0.05), but related with differentiated degree (OR= 0.41, 95% CI 0.25-0.67, P= 0.000 4), lymphatic metastasis (OR= 5.11, 95% CI 2.73-9.56, P <0.000 1), and TNM staging (OR= 0.32, 95% CI 0.20-0.51, P < 0.000 01). Moreover, GLUT-1 had a correlation with the overall survival rate of gastric cancer (HR= 1.61, 95% CI 1.30-1.99, P < 0.000 1). Conclusions GLUT-1 protein expression is higher in gastric cancer tissues than that in normal gastric mucosa, and it is related to tumor differentiation degree, lymph node metastasis, TNM staging. Besides, GLUT-1 may be correlated with poor prognosis of patients with gastric cancer. Key words: Stomach neoplasms; Monosaccharide transport proteins; Meta-analysis