Abstract
The aim of the study was to clarify the role of gastrokine 1 in the process of formation and development of gastric cancer. The expression of gastrokine 1 in gastric cancer and corresponding non-cancerous gastric tissues of 52 gastric cancer patients was assessed with the real-time fluorescence quantitative polymerase chain reaction (RT-PCR) and immunohistochemistry. We also analyzed the relationship between the expression level and clinicopathological characteristics. Gastrokine 1 gene and protein expression in gastric cancer tissues was in both cases significantly lower than in corresponding non-cancerous gastric tissues (both P<0.01), but no significant relationship was found with clinicopathological parameters including tumor location, depth of invasion, differentiation, lymph node metastasis, stage, gender, age and carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) level in peripheral blood preoperation of patients (P>0.05, respectively). Furthermore, gastrokine 1 gene expression was markedly lower in gastric cancer tissues of Helicobacter pylori (HP)-positive patients than negative ones (P<0.05). The result of the study showed that gastrokine 1 might play a significant role in the process of formation and development of gastric cancer as an anti-oncogene. Its effect might be weakened by HP infection.
Highlights
Gastric cancer, one kind of the most common malignant tumors worldwide, is the second leading cause of cancer death
Gastrokine 1 gene and protein expression in gastric cancer tissues was in both cases significantly lower than in corresponding non-cancerous gastric tissues, but no significant relationship was found with clinicopathological parameters including tumor location, depth of invasion, differentiation, lymph node metastasis, stage, gender, age and carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) level in peripheral blood preoperation of patients (P>0.05, respectively)
It is clear that the expression of Gastrokine 1 changes throughout the gastric canceration, and it plays an important role in the process of formation and development of gastric cancer
Summary
One kind of the most common malignant tumors worldwide, is the second leading cause of cancer death. It was estimated there were about 989 thousand new gastric cancer cases and 738 thousand gastric cancer deaths globally one year (Ferlay et al, 2010). Lessening or lack of protective factors may lead gastric mucosa more exposion to harmful substance, which may induce expression changes of gastric cancer genes, and promote happening or development of gastric cancer at last. In the past few years one gene named Gastrokine 1, which had the functions such as protecting gastrointestinal mucosa, promoting mucosa repairment, suppressing cancer and so on, was found (Toback et al, 2003). The relationship between its expression and clinicopathological characteristics of gastric cancer was analysed
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