Abstract
Relationship between E6-E7 lineage sequences, viral loads, and integration of HPV16 in women with atypical squamous cells of undetermined significance (ASCUS) pap smears
Highlights
Mucosal Human Papillomaviruses (HPVs) play a crucial role in the development of malignancies
Infection with high-risk Human Papillomavirus (HPV) is necessary for the development of a cervical lesion, but only a fraction of precursor lesions progress to cancer
The percentage of HPV16 DNA integration, as a marker for high-grade cervical lesions, was demonstrated in some studies [23], while the increased frequency of non-European HPV16 variants in invasive lesions was described by Tornesello et al [43], suggesting greater oncogenicity for the nonEuropean HPV16 variants [44,45,46]
Summary
Mucosal Human Papillomaviruses (HPVs) play a crucial role in the development of malignancies. These viruses are responsible for 99.7% of cervical cancers [1] and are classified as High-Risk (HR) or Low-Risk (LR), based on their association to cervical cancer [2,3]. Persistent infections with certain variants of HPV16, the genotype found in approximately half of all cervical cancers [4], differ in cancer risk These variants diverge in their biological properties; they may become important risk factors in cervical cancer because of possible differences in pathogenicity [5,6,7,8,9]
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