Relationship between decayed teeth and metabolic syndrome: data from 4716 middle-aged male Japanese employees.

Miki Ojima,Atsuo Amano,Shu Kurata

doi:10.2188/jea.je20140132

Miki Ojima, Atsuo Amano + Show 1 more

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https://doi.org/10.2188/jea.je20140132

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Abstract

BackgroundEpidemiological findings regarding the relationship between decayed teeth (DT) and metabolic syndrome (MetS) are scarce. We evaluated the relationship of DT with MetS, obesity, and MetS components in early middle-aged male Japanese employees.MethodsWe cross-sectionally analyzed dental and medical health checkup results from a total of 4716 participants aged 42 or 46 years. Logistic regression models were employed to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) after adjustment for age, breakfast consumption frequency, drinking habits, smoking status, and physical activity.ResultsSignificant differences in the prevalence of MetS, obesity determined by body mass index, and the components of MetS between participating men with and without DT were detected (all P < 0.01). The adjusted OR of MetS was 1.41 (95% CI, 1.14–1.74) for those with 1 or 2 DT, and 1.66 (95% CI, 1.28–2.16) for those with ≥3 DT (P for trend = 0.01), and this significant relationship was observed even in those without periodontal pocket formation (P for trend = 0.03) or missing teeth (P for trend = 0.02). DT was significantly related to overweight/obesity and the MetS components of hypertension, dyslipidemia, and hyperglycemia, with adjusted ORs of 1.35 (95% CI, 1.19–1.53), 1.22 (95% CI, 1.07–1.39), 1.18 (95% CI, 1.03–1.34), and 1.33 (95% CI, 1.13–1.56), respectively. In addition, even in non-overweight/non-obese men, DT was found to be related to dyslipidemia and hyperglycemia, though with marginal significance (P < 0.05).ConclusionsOur findings suggest that having DT is related to MetS in early middle-aged Japanese men directly and through obesity and is independent of health behaviors, periodontal condition, and tooth loss.

Highlights

Metabolic syndrome (MetS) is an established risk factor for atherosclerosis, which greatly contributes to cardiovascular disease
Higher values for Body mass index (BMI), waist circumference (WC), SBP, DBP, TG, and FBS, and lower levels of high-density lipoprotein cholesterol (HDL-C) were observed in participants with decayed teeth (DT) than in those without
The present analysis of health checkup results of middle-aged Japanese male employees showed that the number of DT was significantly related to increased odds of metabolic syndrome (MetS) after adjustments for health behaviors as potential confounders, and this connection was observed even in participants without periodontal pocket formation and those without missing teeth

Summary

Introduction

Metabolic syndrome (MetS) is an established risk factor for atherosclerosis, which greatly contributes to cardiovascular disease. Over the past two decades, increasing epidemiological evidence linking poor oral health and systemic conditions has been presented, with a large amount of research focusing on the possible relationships of periodontal disease with cardiovascular disease[2] and diabetes.[3] Periodontal disease is related to various atherosclerotic risk factors, including obesity, hypertension, dyslipidemia, hyperglycemia, and MetS.[4] One proposed biological pathway linking periodontal disease and atherosclerosis is chronic inflammatory response caused by periodontal pathogens such as Porphyromonas gingivalis.[5]. Conclusions: Our findings suggest that having DT is related to MetS in early middle-aged Japanese men directly and through obesity and is independent of health behaviors, periodontal condition, and tooth loss

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