Abstract
Introduction: This study aimed to perform a meta-analysis on the prevalence of metabolic syndrome (MetS) among patients with asthma and to measure the association asthma has with MetS. Methods: The Web of Science, Medline, Scopus, Embase and Google Scholar were searched using the "Asthma", "Metabolic Syndrome", "Dysmetabolic Syndrome", "Cardiovascular Syndrome", "Insulin Resistance Syndrome", "Prevalence", "Odds Ratio", "Cross-Sectional Studies", and "Case-Control Studies" keywords. All observational studies reporting the prevalence of MetS among people with and without asthma were included in the study. In the presence of heterogeneity, random-effects models were used to pool the prevalence and odds ratios (OR), as measures of association in cross-sectional and case-control/ cohort studies, respectively.Results: The prevalence of MetS among patients with asthma (8 studies) and the OR comparing the prevalence of MetS among patients with and without asthma (5 studies) were pooled separately. The pooled prevalence of MetS among patients with asthma was found to be 25% (95% confidence interval (CI): 13%–38%). In contrast, the overall pooled OR for MetS in patients with asthma, compared to healthy controls, was 1.34 (95% CI: 0.91–1.76), which was not statistically significant. Conclusion: The prevalence of MetS was relatively high in patients with asthma. Furthermore, the odds of MetS was higher in patients with asthma, compared to healthy controls, although this difference was not statistically significant. More original studies among different populations are needed in order to more accurately examine the association between asthma and MetS, as well as the relationship asthma has with the individual components of MetS.
Highlights
This study aimed to perform a meta-analysis on the prevalence of metabolic syndrome (MetS) among patients with asthma and to measure the association asthma has with MetS
All studies included in this systematic review and meta-analysis were published in English during the period January 2010 to June 2018, and the ages of the participants ranged from 12-78 years old
The present study revealed that the prevalence of MetS was a lot higher (25%) in patients with asthma, meaning that this syndrome needs to be addressed and controlled in patients with asthma
Summary
This study aimed to perform a meta-analysis on the prevalence of metabolic syndrome (MetS) among patients with asthma and to measure the association asthma has with MetS. Asthma is one of the most common respiratory ailments and there are a number of treatments available, these are not always effective for patients with severe clinical symptoms.[1,2,3] A recent literature search reported that obesity was an important factor that disrupts the control of asthma symptoms and results in a reduced response to treatment.[4] a robust epidemiological association between asthma and obesity has recently become well established.[5,6,7,8] Asthma has been associated with other components of metabolic syndrome (MetS), such as hypertension and insulin resistance, irrespective of elevated body mass.[8,9,10,11] According to reports from the World Health Organization (WHO), obesity has shown a drastic increase in recent decades. We aimed to conduct a meta-analysis to examine the association between asthma and MetS using published observational studies
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
