Relationship between content of hepatocyte growth factor and nuclear matrix protein 22 in urine and the stage and grade of bladder uroepithelium carcinoma

Abstract

：Objective To evaluatethe relationship of the hepatocyte growth factor (HGF) and the nuclear matrix protein 22(NMP22) in urine and the stage and grade of bladder uroepithelium carcinoma.Methods Atotal of 48 post-operative patients (males 39, females 9) with bladder cancer enrolled inthis study were perfused with THP. The voided urine of all the patients before and 6months after perfusion were recovered selectively. HGF and NMP22 ELISA kits were used todetect bladder cancer. Results The recurrence rate was 12.5 %. The HGF level had positivecorrelation with the stage and grade of bladder uroepithelium carcinoma (P ＜0.05). The NMP22 level hadpositive correlation with the grade of bladder cancer. The sensitivity and specificity ofHGF, NMP22 and cytology were 100 % (6/6), 83.3 % (5/6), 66.7 %(4/6) and 61.9 % (26/42),57.1% (24/42), 97.6 % (41/42), respectively. Conclusion The HGF and NMP22 are bothvaluable tumor markers in the urine of bladder uroepithelium carcinoma. They have intimaterelation with the stage and grade of bladder uroepithelium carcinoma. Hence combined withcytology, they could be selected as the significance level of early screening anddiagnosing. Key words: Urinary bladder neoplasms; Hepatocyte growth factor; ,Nuclear matrix-associated proteins