Abstract
Objective To investigate the relationship between carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) expression and angiogenesis in gastric cancer.Methods CEACAM1 and CD34 expression was detected by immunohistochemistry (IHC) in 174 cases of gastric cancer and 40 cases of nonneoplastic gastric tissues.Results No CEACAM1 expression was found in nonneoplastic gastric mucosa tissues.CEACAM1 expression was classfied as high and low (69.0％ vs.31.0％),the CD34-microvessel density (MVD) expression between them was significantly different (57.32 ± 6.56 vs.44.26 ± 7.25,P ＜ 0.05).Coexpression of CEACAM1 and CD34-MVD was elevated and significantly different from nonneoplastic to neoplastic lesions(P ＜0.05).Moreover,high CEACAM1 expression and CD34-MVD were closely associated with degree of tumor differentiation,nodal metastasis and TNM staging.Conclusion Up-regulating CEACAM1 may participate in tumor angiogenesis,and promote its capability of invasion and metastasis. Key words: Gastric cancer; Carcinoembryonic antigen-related cell adhesion molecule 1; CD34 ; Immunohistochemistry
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