Relationship between C-reactive protein and prognosis of ischemic stroke

Abstract

Objective To investigate the relationship between changes in C-reactive protein and prognosis of ischemic stroke.Methods C-reactive protein were detected in 73 cases with ischemic stroke serum and selected be as a study group ,while collecting ,41 cases of healthy volunteers as the control group at the same period whose C -reac-tive protein was detected too .The study group was followed up for one year then compared C-reactive protein changes of two groups.Results The C-reactive protein in patients of the study group had average content （15.16 ±7.01）mg/L, which was significantly higher than （4.51 ±1.36）mg/L of the control group,the difference was statistically signifi-cant（ t=7.153,P〈0.05）;The study group of patients with large and medium infarct size ,their C-reactive protein levels were （18.13 ±10.07） mg/L,（15.21 ±7.34） mg/L,significantly greater than patients′with the small size of the infarct（9.95 ±6.14）mg/L,the difference was statistically significant （t=7.316,6.541,all P〈0.05）;The levels of C-reactive protein in heavy and medium patients were （19.13 ±12.24）mg/L,（16.32 ±8.16）mg/L respectively, significantly higher than the mild patients′（9.93 ±5.41）mg/L,the difference was statistically significant（t=8.153, 7.692,all P〈0.05）;During follow-up,the serum C-reactive protein levels in patients with recurrence of stroke and death were （16.12 ±8.67）mg/L,（19.17 ±11.36）mg/L,significantly higher than the better prognosis of patients （11.32 ±8.43）mg/L,the difference was statistically significant （t=7.583,8.751,all P〈0.05）.Conclusion The changes of C-reactive protein levels can be as a prognostic indicator of stroke in clinical . Key words: Brain ischemia; C-reactive protein; prognosis